化学
肽
并行传输
氨基酸
细胞通透性
生物物理学
结构-活动关系
磁导率
半胱氨酸
环肽
生物化学
体外
立体化学
膜
酶
生物
作者
Shelley D. Minteer,Ed Oliver,Kelly M. Kitchens,John Vere,Sefik S. Alkan,Amir P. Tamiz
标识
DOI:10.1016/j.bmcl.2008.07.028
摘要
AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile.
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