Selective enrichment of proteins for MALDI-TOF MS analysis based on molecular imprinting

Molecularly imprinted polymers (MIPs) were applied for selective enrichment of proteins in MALDI-TOF MS analysis for the first time. MIPs were achieved simply via immobilization of template lysozyme (Lyz) on core-shell magnetic nanoparticles and self-polymerization of dopamine (DA).