Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Key Points A half loss of RUNX1 activity leads to defects in primitive erythropoiesis, megakaryopoiesis, and proplatelet formation. An almost complete loss of RUNX1 activity leads to the amplification of the granulomonocytic compartment with increased genomic instability.