Antimicrobial Properties of Metal-Organic Frameworks

Exploring novel antimicrobial agents has become increasingly imperative in the face of escalating antimicrobial resistance. Metal-organic frameworks (MOFs), a class of crystalline materials renowned for their remarkable porosity and versatile functionalities, have emerged as promising candidates for combating microbial infections. This chapter offers a comprehensive overview of the antimicrobial properties of MOFs, shedding light on their synthesis, mechanisms of action, and potential applications in diverse fields. Commencing with a discussion on the global challenges of antimicrobial resistance, this chapter underscores the urgency for innovative approaches in antimicrobial research. The unique attributes of MOFs, including their tunable structures and the ability to encapsulate diverse bioactive molecules are examined in the context of designing effective antimicrobial agents. The rational design strategies employed to enhance the antimicrobial activity of MOFs are elucidated, encompassing the incorporation of metal nodes, functionalization of organic ligands, and synergistic combination with conventional antibiotics. The mechanisms underpinning the antimicrobial action of MOFs are explored, encompassing aspects such as membrane disruption, reactive oxygen species generation, and targeted intracellular delivery. The need for standardized testing methodologies, in-depth toxicity assessments, and thorough understanding of MOF-microbe interactions is emphasized in this chapter. The integration of computational approaches and the translation of laboratory findings to practical applications are identified as pivotal steps in harnessing the full potential of MOFs in the fight against antimicrobial resistance. As the global healthcare community seeks innovative strategies to address the pressing issue of antimicrobial resistance, MOFs stand at the forefront, poised to contribute transformative solutions in the pursuit of effective antimicrobial interventions.