糖皮质激素
胎儿
医学
队列
内分泌学
内科学
出生体重
队列研究
生理学
绳索
怀孕
产科
生物
外科
遗传学
作者
Duan Cai,Qing-Qing Li,Zeeshan Mohammed,Wei-Chun Chou,Jinbo Huang,Min-Li Kong,Yaoqin Xie,Yunjiang Yu,Guocheng Hu,Jianying Qi,Yang Zhou,Tan Wang,Lizi Lin,Rongliang Qiu,Guang‐Hui Dong,Xiao‐Wen Zeng
标识
DOI:10.1021/acs.est.2c08831
摘要
Glucocorticoid plays a key role in the growth and organ maturation of fetus. However, the effect of glucocorticoid on the association between per- and polyfluoroalkyl substance (PFAS) exposure and fetal growth is still unknown. We detected cord cortisol (active glucocorticoid in human) and 34 PFAS concentrations in the maternal serum samples, which were collected from 202 mother-fetus pairs in the Maoming Birth Cohort from 2015 to 2018. The mediation effect of cord cortisol on the association between maternal PFAS and the neonatal growth index (NGI) was estimated. We found that higher PFAS concentrations were associated with lower NGI in terms of ponderal index, birth weight (BW), head circumference (HC), and its z-scores (BWZ and HCZ) (P < 0.05). Fetal cortisol could mediate 12.6-27.3% of the associations between PFAS and NGI. Specifically, cord cortisol mediated the association between branched perfluorooctane sulfonate (branched PFOS) and HCZ by 20.4% and between perfluorooctanoate (PFOA) and HCZ by 27.3%. Our findings provide the first epidemiological data evincing that fetal cortisol could mediate the association between prenatal PFAS exposure and fetal growth. Further investigations are recommended to elucidate the interactions among cord cortisol, PFAS, and fetal growth.
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