放射增敏剂
生物相容性
克隆形成试验
体内
纳米颗粒
化学
体外
辐照
放射治疗
纳米技术
癌症研究
材料科学
核化学
医学
生物化学
生物
内科学
有机化学
核物理学
生物技术
物理
作者
Hamid Rashidzadeh,Farzad Seidi,Mohammadreza Ghaffarlou,Marziyeh Salehiabar,Jalil Charmi,Kadir Yaray,Hamed Nosrati,Yavuz Nuri Ertaş
标识
DOI:10.1016/j.ijbiomac.2023.123273
摘要
Noble metals as high atomic number elements can localize X-ray radiation within tumor cells by exploiting different mechanisms. Here, alginate (Alg)-coated platinum nanoparticles (Pt@Alg) were synthesized, characterized, and implemented as a radiosensitizer to enhance X-ray therapeutic efficacy in breast cancer in vitro and in vivo. Alg not only improves the biocompatibility of the radioenhancer, but also stabilizes the nanoparticles. Pt@Alg was studied by different characterization methods including DLS, STEM, Fe-SEM, XRD, XPS, FT-IR and UV-Vis spectrophotometry. The nanosystem provided a higher level of intracellular ROS in malignant cells and enhanced cancer cell death under X-Ray irradiation. Clonogenic assay also demonstrated the radiosensitizing properties of the nanosystem, in vitro. In vivo result show tumor growth restraining properties of the nanosystem when it was administrated along with X-Ray irradiation. Histopathology results confirmed the impact of nanosystem and X-ray co-treatment, as well. Altogether, the importance of radiosensitizers for improving radiotherapy outcomes was highlighted.
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