Expression Characteristics of SYPL1 in Oral Squamous Cell Carcinoma and Its Correlation With Prognosis

SYPL1 is significantly upregulated in OSCC tissues and shows potential as a diagnostic biomarker for distinguishing tumours from normal samples, particularly in early detection. Elevated SYPL1 expression is associated with poor prognosis in patients with OSCC, especially in T3 and N0 stages, suggesting that it could complement the TNM staging system for improved risk stratification. Mechanistically, the negative correlation between SYPL1 expression and infiltrating cytotoxic and dendritic cells implies a possible role in immune modulation, but this requires functional validation. Future studies should focus on elucidating the functional mechanisms of SYPL1 to assess its therapeutic relevance.