PI3K/AKT/mTOR通路
安普克
信号转导
糖尿病
氧化应激
医学
自噬
胰岛素
胰岛素受体
内分泌学
胰岛素抵抗
生物
内科学
生物信息学
细胞生物学
生物化学
激酶
细胞凋亡
蛋白激酶A
作者
Ziyuan Wang,Zhijun Cao,Zhiying Yue,Zhengfeng Yang
标识
DOI:10.3389/fendo.2023.1216907
摘要
Diabetic Mellitus (DM), a chronic metabolic disorder disease characterized by hyperglycemia, is mainly caused by the absolute or relative deficiency of insulin secretion or decreased insulin sensitivity in target tissue cells. Dihydromyricetin (DMY) is a flavonoid compound of dihydroflavonol that widely exists in Ampelopsis grossedentata. This review aims to summarize the research progress of DMY in the treatment of DM. A detailed summary of related signaling induced by DMY are discussed. Increasing evidence implicates that DMY display hypoglycemic effects in DM via improving glucose and lipid metabolism, attenuating inflammatory responses, and reducing oxidative stress, with the signal transduction pathways underlying the regulation of AMPK or mTOR/autophagy, and relevant downstream cascades, including PGC-1α/SIRT3, MEK/ERK, and PI3K/Akt signal pathways. Hence, the mechanisms underlying the therapeutic implications of DMY in DM are still obscure. In this review, following with a brief introduction of the absorption, metabolism, distribution, and excretion characteristics of DMY, we summarized the current pharmacological developments of DMY as well as possible molecular mechanisms in the treatment of DM, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.
科研通智能强力驱动
Strongly Powered by AbleSci AI