炎症
发病机制
癌症
结肠炎
免疫学
医学
程序性细胞死亡
活性氧
机制(生物学)
脂质过氧化
癌症研究
结直肠癌
氧化应激
生物
细胞凋亡
细胞生物学
内科学
认识论
哲学
生物化学
作者
Xiaoli Zhang,Yiming Ma,Guoqing Lv,Hongying Wang
标识
DOI:10.3389/fphar.2023.1095366
摘要
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.
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