医学
荟萃分析
优势比
超重
2型糖尿病
内科学
置信区间
观察研究
糖尿病
流行病学
肥胖
队列研究
疾病
内分泌学
作者
F. Barde,L. Pacoureau,Alexis Elbaz,Raphaèle Séror,Yann Nguyen
标识
DOI:10.1093/rheumatology/keaf164
摘要
Abstract Objectives We aimed to analyze the association between cardiovascular risks factors and the onset of giant cell arteritis (GCA) through a systematic review and meta-analysis of observational studies. Methods Three databases (MEDLINE, EMBASE, WEB OF SCIENCE) were systematically reviewed. Epidemiological studies on the association between six cardiovascular risk factors (type 2 diabetes, hypertension, dyslipidaemia, smoking, overweight/obesity, history of a cardiovascular disease) and the risk of GCA were eligible. Risk of bias was assessed using the ROBINS-E scale. Pooled associations for studies assessing the same outcome were reported as odds ratios (OR) and their 95% confidence interval (CI). Results The search strategy identified 4,210 references, of which 43 studies were analyzed and 17 were included in the meta-analysis (11 case-control studies, four cohort studies). An inverse association was found between type 2 diabetes and risk of GCA (OR = 0.75, 95% CI 0.61–0.93) and whereas history of cardiovascular disease was positively associated with GCA with risk (OR = 1.28, 95% CI 1.18–1.38). We found a trend towards a decreased risk of GCA in overweight participants (OR 0.64; 95% CI 0.41–1.00). Conclusion Our study showed an inverse association of type 2 diabetes and a positive association of a history of cardiovascular disease with GCA risk. There is also a trend towards an inverse association with overweight. The pathophysiological mechanisms underlying these findings may involve an effect of cardiovascular risk factors themselves, a condition underlying these factors such as diet, or a condition following their diagnosis such as their treatment.
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