再生(生物学)
肝再生
肝细胞
生物
再生过程
病理
医学
生物信息学
细胞生物学
生物化学
体外
作者
Svetlana A. Rodimova,Artem Mozherov,Vadim Elagin,Maria Karabut,Ilya Shchechkin,Д. В. Козлов,Dmitry Krylov,Alena I. Gavrina,Nikolai Bobrov,В. Е. Загайнов,Elena V. Zagaynova,Daria Kuznetsova
摘要
Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneration can occur in the presence of concomitant hepatic pathology, which is a key factor reducing the liver's regenerative potential. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or to directly stimulate liver regeneration. This review describes the known mechanisms of normal liver regeneration and factors that reduce its regenerative potential, primarily at the level of hepatocyte metabolism, in the presence of concomitant hepatic pathology. We also briefly discuss promising strategies for stimulating liver regeneration and those concerning methods for assessing the regenerative potential of the liver, especially intraoperatively.
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