机械敏感通道
瞬时受体电位通道
神经科学
谷氨酸受体
视网膜
机制(生物学)
超声波
调制(音乐)
刺激
化学
生物物理学
细胞生物学
生物
受体
离子通道
物理
生物化学
量子力学
声学
作者
Shun-Yi Zhuo,Hui Gong,Guofeng Li,Weibao Qiu,Hairong Zheng,Pei-Ji Liang
出处
期刊:Journal of Neural Engineering
[IOP Publishing]
日期:2023-06-01
卷期号:20 (3): 036025-036025
被引量:1
标识
DOI:10.1088/1741-2552/acd7a4
摘要
Abstract Objective. Ultrasound has been shown to modulate the activity of retinal ganglion cells (RGCs) in mice, but the mechanism remains poorly understood. This study aims to address this question. Approach. Multi-electrode recordings together with pharmacological methods were used to investigate the possible cellular/circuitry mechanism(s) underlying the neuronal modulation induced by low-frequency (1 MHz), low-intensity ( I SPTA 0.5 W cm −2 ) ultrasound stimulation. Main results. We found that ultrasound activated mechanosensitive channels (transient receptor potential vanilloid 4 (TRPV4) channels are involved) in Müller cells, causing the release of glutamate, which acts on the extrasynaptic N -methyl-D-aspartate receptors of RGCs, thus leading to the modulation of neuronal activity. Significance. Our results reveal a novel mechanism of low-frequency, low-intensity ultrasound modulation, involving TRPV4 as a mechanosensitive target for ultrasound and glutamate as an essential mediator of neuron-glia communication. These findings also demonstrate that the mechanical-force-mediated pathway is important for retinal signal modulation during visual processes, such as visual accommodation.
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