分子内力
立体中心
化学
壬烷
赫克反应
戒指(化学)
立体化学
级联反应
级联
组合化学
催化作用
对映选择合成
有机化学
钯
色谱法
作者
Nagayasu Nakajima,Eiji Yoshida,Tatsuya Toma,Yoshitake Nishiyama,Masayuki Inoue,Tohru Fukuyama,Satoshi Yokoshima
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-28
卷期号:24 (44): 8228-8232
标识
DOI:10.1021/acs.orglett.2c03357
摘要
A synthetic route to ecteinascidin 743 has been established via an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane skeleton while controlling the two contiguous stereogenic centers. The strategically formed five-membered ring was oxidatively cleaved to generate a dialdehyde intermediate, from which the B ring of ecteinascidin 743 was constructed.
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