The effect of erythropoietin on ?-glutamyltransferase during ischemia reperfusion injury in rats

The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean γ-glutamyltransferase (γGT) levels.  Materials and methods: 40 rats of mean weight 247.7 g were used in the study. γGT levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly decreased the γGT levels by 12.70%                            +13.11% results of paired t-test (p= 0.3541). Reperfusion time kept non-significantly increased the γGT levels by 6.35%+13.24% (P=0.6264). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in keeping decreased the γGT levels by 4.62%+7.97% (P= 0.5534). Conclusions are that erythropoietin administration interacted or not with reperfusion time  have non significant short – term decreasing effects on γGT levels.