纳米复合材料
甘露糖受体
甘露糖
化学
炎症性肠病
药物输送
巨噬细胞
柠檬酸
毒品携带者
靶向给药
菊粉
体内
材料科学
体外
生物物理学
核化学
纳米技术
生物化学
医学
有机化学
病理
生物
疾病
生物技术
作者
Qijuan Sun,Muhammad Arif,Zhe Chi,Guotao Li,Chenguang Liu
标识
DOI:10.1016/j.ijbiomac.2020.12.094
摘要
In the present experimental series, we have developed a novel nanocomposite to target activated macrophages in the colon with real time imaging and therapeutic capabilities. This binary nanocomposite was formed by the covalent conjugation of mannosylated NPs (Man-NPs) with carbon dots (CDs). Man-NPs were prepared using a self-assembly method based on mannosylated decamethylenediamine-grafted carboxymethyl inulin amphiphilic acid. While, the CDs were synthesized using a simple bottom-up process using citric acid monohydrate and diethylenetriamine, which were tightly bonded to the Man-NPs surface by carbodimide coupling. The resulting nanocomposite had a uniform size of 241.3 nm with a negative charge and a high drug casing density of 25.54 wt% and blue self-fluorescence were emitted. Whereas, in vitro observation of cellular uptake indicated the greater nanocomposite uptake in inflamed macrophage as compared to the untreated macrophage and mannose receptor-negative cell lines, 4T1 respectively. However, in vivo bio distribution exhibited a large number (60%) of CDs/Man-NPs nanocomposite accumulated in the inflamed colon of colitis mice. It should be noted that the novel nanocomposite, as macrophage-targeted drug delivery, could have promise for the treatment of inflammatory bowel disease (IBD).
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