The Effect of a Plasma With Platelet-rich Fibrin in Bone Regeneration and on Rate of Orthodontic Tooth Movement in Adolescents

The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF), placed in extraction sockets, on bone regeneration and orthodontic tooth movement in adolescents. Fourty extraction sockets from twenty patients requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. The bone regeneration and the amount of orthodontic tooth movement was evaluated.