Biological mechanisms and clinical significance of isocitrate dehydrogenase 1 mutation in glioma

Isocitrate dehydrogenase 1 (IDH1), a key rate-limiting enzyme in tricarboxylic acid cycle, is found within the cytoplasm and peroxisomes. In recent years, IDH1 mutation is discovered in most glioma and its large scale metabolites, 2-hydroxyglutarate, may be involved in tumor as potential carcinogens, and is shown to be closely related to better patients′ survival as well. IDH1 mutation is anticipated to be a novel genetic biomarker which will guide the treatments of clinical glioma. Key words: Isocitrate dehydrogenase 1; Mutation; Glioma; Tumor markers, biological; Prognosis