A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment (Adv. Healthcare Mater. 5/2026)

Microphysiological Systems In the Research Article (DOI: 10.1002/adhm.202502711), Curtis R. Warren, Roger D. Kamm, and co-workers develop a microphysiological system that interfaces human engineered muscle tissue with an inflamed adipose-macrophage co-culture to recapitulate obesity-associated muscle dysfunction, revealing impaired contractility, elevated pro-inflammatory cytokine secretion, and metabolically dysregulated gene expression.