Zebrafish Models of Epilepsy and Epileptic Seizures

Zebrafish, a small vertebrate model well-known in developmental biology, is now widely recognized as an important organism for modeling human diseases. Particularly, in the past decade, zebrafish has emerged as a novel and promising model in the field of epilepsy and drug discovery. In this chapter, we aim to give a comprehensive overview of the success and potential of zebrafish epilepsy research. We describe zebrafish models of epilepsy and epileptic seizures generated by various pharmacological and genetic manipulations, with a focus on current methods to monitor and characterize seizure-related activities. Moreover, future perspectives in zebrafish epilepsy modeling and epilepsy research are highlighted. Finally, we discuss challenges and strategies for further translational research in zebrafish epilepsy field.