生物
原发性渗出性淋巴瘤
小RNA
基因沉默
溶解循环
发病机制
病毒
卡波西肉瘤相关疱疹病毒
病毒学
寡核苷酸
转录组
计算生物学
基因
遗传学
疱疹病毒科
免疫学
基因表达
病毒性疾病
作者
Hosni A. M. Hussein,Mohammad A. Alfhili,Pranaya Pakala,Sandra Simon,Jaffer Hussain,James A. McCubrey,Shaw M. Akula
标识
DOI:10.1016/j.virusres.2019.03.024
摘要
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman Disease (MCD). Recent mechanistic advances have discerned the importance of microRNAs in the virus–host relationship. KSHV has two modes of replication: lytic and latent phase. KSHV entry into permissive cells, establishment of infection, and maintenance of latency are contingent upon successful modulation of the host miRNA transcriptome. Apart from host cell miRNAs, KSHV also encodes viral miRNAs. Among various cellular and molecular targets, miRNAs are appearing to be key players in regulating viral pathogenesis. Therefore, the use of miRNAs as novel therapeutics has gained considerable attention as of late. This innovative approach relies on either mimicking miRNA species by identical oligonucleotides, or selective silencing of miRNA with specific oligonucleotide inhibitors. Here, we provide an overview of KSHV pathogenesis at the molecular level with special emphasis on the various roles miRNAs play during virus infection.
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