Sugar substitutes have sweet taste (like sugar), but have no calories or carbohydrates. The artificial sweeteners don’t contribute to weight gain, don’t cause decay and don’t raise blood sugar levels. Since sugar substitutes are many times sweeter than sugar, only small amounts are needed to sweeten foods and beverages. All, except saccharin, are approved as safe for use during pregnancy. The aim of the studi was to make research based on the questions: are the artificial sweeteners healthy and how each of them influence on oral health. For realisation of the study aim, research of the scientific base (PubMed, Medline and MedScape) was made. The generic name, chemical structure, product name and details, positive and negative attribute, will be shown as table chart. Sugar substitutes have been thoroughly tested by The Food and Drug Administration (FDA) and have been established as safe for use as tabletop sweeteners or as ingredients in foods and beverages. Keywords Food, Health, Oral, Sweeteners, Tooth.