神经炎症
小胶质细胞
化学
药理学
脊髓损伤
炎症
药物输送
生物相容性
细胞生物学
脊髓
医学
免疫学
神经科学
生物
有机化学
作者
Xianghang Chen,Beini Wang,Yuqin Mao,Abdullah Al Mamun,Man Wu,Shuyi Qu,Zhaoxiong Xie,Jinjing Zhang,Jing Pan,Yunsen Zhu,Tingting Mo,Chang Jiang,Linjun Yang,Jian Xiao
标识
DOI:10.1016/j.cej.2022.137882
摘要
Inflammation is a pivotal molecular event in secondary spinal cord injury (SCI). However, chloroquine (CQ) is an anti-malarial drug with remarkable anti-inflammatory effects. Zein is a biodegradable biomaterial derived from natural-plant protein and is widely applied in drug sustained-release carriers due to its promising biocompatibility and biodegradability. In this research, we investigated the significant effects and underlying molecular mechanisms of zein nanoparticles (NPs) loaded with CQ in SCI. More importantly, we found that local delivery of Zein-CQ NPs after SCI could significantly improved functional recovery, inhibited neuronal apoptosis, alleviated neuroinflammation and enhanced M2 phenotype microglia polarization. Mechanistically, our findings further demonstrated that local administration of Zein-CQ NPs inhibited activation of the MAPK/NF-κB signaling pathway after SCI in rats. Moreover, Zein-CQ NPs reduced the release of pro-inflammatory factors and augmented the protein expression of M2 phenotype microglia in lipopolysaccharide (LPS)-stimulated BV2 cells. Our findings imply that local delivery of Zein-CQ NPs produces promising therapeutic benefits for the treatment and management of SCI.
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