乳腺癌
丹麦克朗
生物标志物
医学
雌激素受体
内科学
癌症
孕酮受体
肿瘤科
Wnt信号通路
胃肠病学
内分泌学
生物
信号转导
生物化学
作者
Jintao Liu,Wenhui Guo,Jiayi Sun
出处
期刊:Minerva Medica
[Edizioni Minerva Medica]
日期:2017-06-01
卷期号:108 (4)
被引量:5
标识
DOI:10.23736/s0026-4806.17.04807-8
摘要
The serum levels of Dickkopf-1 (DKK1), a secreted Wnt family protein, are different in patients suffering various types of cancers. In the present study, we aim to explore the diagnostic value of DKK1 as a new biomarker in breast cancer.Serum was collected from 38 patients with breast cancer and 23 healthy controls. Serological levels of DKK1 were examined by enzyme-linked immunosorbent assay (ELISA). Significance and diagnostic performance including receiver operator characteristic (ROC) and areas under the curve were determined by SPSS software.Serum level of DKK1 was significantly increased in breast cancer patients compared to the healthy controls (P˂0.05). The expression levels of CA15-3 were also evaluated in patients suffering from breast cancer in comparison with healthy controls (P˂0.05). AUC for DKK1 and CA15-3 were 0.81 and 0.64 respectively. Sensitivity and specificity of DKK1 were more than CA15-3 in earlier stage of breast cancer. DKK1 expression in HER-2, estrogen receptor (ER) and progesterone receptor (PR) positive patients was decreased compared with HER-2, ER and PR negative patients.We found that the expression level of DKK1 in serum was increased in breast cancer patients, suggesting that serum expression level of DKK1 could be a useful biomarker in breast cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI