Abstract The impact of tropical cyclones (TCs) on the CO2 partial pressure at the sea surface (pCO2sea) and air‐sea CO2 flux (FCO2) in the Bay of Bengal (BoB) was quantified based on satellite data and in situ observations between November 2013 and January 2017. The in situ observations were made at the BoB Ocean Acidification mooring buoy. A weak time‐mean net source of 55.78 ± 11.16 mmol CO2 m−2 year−1 at the BoB Ocean Acidification site was estimated during this period. A wide range in increases of pCO2sea (1.0–14.8 μatm) induced by TCs occurred in postmonsoon (October–December), and large decreases of pCO2sea (−14.0 μatm) occurred in premonsoon (March–May). Large vertical differences in the ratio of dissolved inorganic carbon (DIC) to total alkalinity (TA) in the upper layer (ΔDIC/TA) were responsible for increasing pCO2sea in postmonsoon. Relatively small values of ΔDIC/TA were responsible for decreasing pCO2sea in premonsoon. Five TCs (Hudhud, Five, Kyant, Vardah, and Roanu) were considered. Hudhud significantly enhanced CO2 efflux (18.49 ± 3.70 mmol CO2/m2) in oversaturated areas due to the wind effect during the storm and wind‐pump effects after the storm. Vardah insignificantly changed FCO2 (1.22 ± 0.24 mmol CO2/m2) in undersaturated areas because of the counteraction of these two effects. Roanu significantly enhanced CO2 efflux (19.08 ± 3.82 mmol CO2/m2) in highly oversaturated conditions (ΔpCO2 > 20 μatm) since the wind effect greatly exceeded the wind‐pump effects. These five TCs were estimated to account for 55 ± 23% of the annual‐mean CO2 annual efflux, suggesting that TCs have significant impacts on the carbon cycle in the BoB.