化学
伊萨丁
多米诺骨牌
催化作用
立体选择性
吲哚试验
组合化学
一锅法合成
烷基
环境友好型
绿色化学
有机化学
反应机理
生态学
生物
作者
Halimeh Hajighasemi,Afshin Yazdani‐Elah‐Abadi,Nasim Shams
标识
DOI:10.1080/10406638.2017.1355326
摘要
Magnetic iron(III) oxide nanoparticles (Fe3O4 MNPs) have been used as a readily available, highly efficient, and recyclable catalyst for the green and stereoselective synthesis of novel functionalized 3-indol-3-yl-oxoindolin-3-yl-3-acrylates from a one-pot, two-step, four-component reaction of arylamines, alkyl propiolates, isatin, and indole in EtOH under reflux conditions in good yields. The domino environmentally friendly methodology with excellent green chemistry credentials, such as using the low loading of reusable, nontoxic, easy to handle catalyst, shorter reaction time, avoidance of hazardous organic solvents, and straightforward workup (the catalyst can be easily separated from the reaction mixture by an external magnet), may find a wide range of applications.
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