后代
海马体
海马结构
内分泌学
纽恩
内科学
生物
识别记忆
免疫组织化学
医学
神经科学
怀孕
遗传学
认知
作者
Nor Athirah Kamaliah Ahmad Tarmizi,Naufal Kushairi,Chia Wei Phan,Vikineswary Sabaratnam,Murali Naidu,Pamela David
出处
期刊:Journal of Medicinal Food
[Mary Ann Liebert]
日期:2022-03-01
卷期号:25 (3): 230-238
被引量:2
标识
DOI:10.1089/jmf.2021.k.0121
摘要
Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of β-glucan-rich Pleurotus pulmonarius (βgPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development. Female ICR mice were fed with normal diet (ND), ND with βgPp, high-fat diet (HFD), or HFD with βgPp for 3 months followed by behavioral test and mating. Immunohistochemistry for the expression of neuronal nuclear protein (NeuN) and ionized calcium binding adaptor molecule-1 (Iba-1) in the hippocampus was carried out. βgPp significantly enhanced short-term object recognition memory in HFD-fed mice. βgPp also ameliorated the histological alterations and neuronal loss and increased Iba-1-positive microglia in the hippocampus regions of HFD-fed mice and their male offspring. These findings demonstrated that βgPp supplementation attenuated the effects of HFD on object recognition memory and the alterations on the hippocampal regions of maternal mice and their male offspring.
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