Causal network between periodontitis and systemic inflammation: Triangulating evidence from Mendelian randomization and sequencing datasets

This study explored the bidirectional causal relationship between periodontitis and systemic inflammation, demonstrating a causal relationship between periodontitis and specific circulating inflammatory proteins and immune cell phenotypes, indicating that the treatment of periodontitis needs to consider the systemic inflammatory state and that the systemic inflammatory state may be involved in the link between periodontitis and systemic diseases.