化学
串联
路易斯酸
催化作用
路易斯酸催化
内酯
组合化学
有机化学
级联反应
材料科学
复合材料
作者
Mingjing OuYang,Jun Ouyang,Yunhui Dong,Jinwei Li,Wen Yang
标识
DOI:10.1021/acs.joc.4c00314
摘要
A Lewis acid-catalyzed tandem reaction strategy for the construction of a dihydrophenalene-lactone tetracyclic skeleton has been disclosed. Starting with 2-naphthol-tethered ketones and active methylene esters, the tandem reaction catalyzed by Sc(OTf)3 proceeded well to afford an array of dihydrophenalene-fused lactones with moderate to high efficiency and diastereoselectivity. Moreover, the synthetic utility of this protocol was demonstrated by easy gram-scale preparation and diverse product transformations.
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