Photochemical Cross‐Coupling Enables Csp3−C Bond Formation by C−H Homolytic Cleavage: New Developments and Perspectives

Abstract Over the past decade with the relaunch of photochemistry, photochemical cross‐coupling reactions became an excellent tool for the formation of C−C bond under mild reaction conditions. C(sp3)−H functionalization of inert substrates, combined with modern transition metal catalysis, provides a powerful tool in organic synthesis. A variety of elegant strategies to initiate a HAT event have been developed, generating alkyl radicals that can be easily intersected with a metal. This review conceptualizes the recent developments in this area, linking them with the seminal contributions that pioneered this research field.