HMGB1 Accelerates Wound Healing by Promoting the Differentiation of Epidermal Stem Cells via the “HMGB1-TLR4-Wnt/Notch” Axis

Impairments in the differentiation and migratory capacity of epidermal stem cells (ESCs) are pivotal factors contributing to delayed wound healing. High mobility group box1 (HMGB1) has recently emerged as a potential target for tissue repair. Therefore, we aimed to investigate the role and molecular mechanisms of HMGB1 in ESCs during the wound-healing process.