生物
生长素
拟南芥
细胞生物学
磷酸化
激酶
蛋白质组
信号转导
生长素极性运输
蛋白质磷酸化
基因
蛋白激酶A
遗传学
突变体
作者
André Kuhn,Mark Roosjen,Sumanth K. Mutte,Shiv Mani Dubey,Vanessa Polet Carrillo Carrasco,Sjef Boeren,Aline Monzer,Jasper J. Koehorst,Takayuki Kohchi,Ryuichi Nishihama,Matyáš Fendrych,Joris Sprakel,Jiřı́ Friml,Dolf Weijers
出处
期刊:Cell
[Elsevier]
日期:2023-12-01
标识
DOI:10.1016/j.cell.2023.11.021
摘要
The plant-signaling molecule auxin triggers fast and slow cellular responses across land plants and algae. The nuclear auxin pathway mediates gene expression and controls growth and development in land plants, but this pathway is absent from algal sister groups. Several components of rapid responses have been identified in Arabidopsis, but it is unknown if these are part of a conserved mechanism. We recently identified a fast, proteome-wide phosphorylation response to auxin. Here, we show that this response occurs across 5 land plant and algal species and converges on a core group of shared targets. We found conserved rapid physiological responses to auxin in the same species and identified rapidly accelerated fibrosarcoma (RAF)-like protein kinases as central mediators of auxin-triggered phosphorylation across species. Genetic analysis connects this kinase to both auxin-triggered protein phosphorylation and rapid cellular response, thus identifying an ancient mechanism for fast auxin responses in the green lineage.
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