外膜
神经修复
材料科学
粘附
纳米技术
生物医学工程
周围神经
解剖
医学
复合材料
作者
Duhwan Seong,Yeon-Sun Choi,In Cheul Choi,Jaebeom Lee,Jae Hyuk Choi,Ji Hun Park,Jae Jun Nam,Jaewon Ju,Hyun Jae Ryoo,Donghee Kwak,Joonyeol Lee,Seong‐Gi Kim,Dong Hwee Kim,Jong Woong Park,Mikyung Shin,Donghee Son
标识
DOI:10.1002/adma.202307810
摘要
Abstract The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti‐inflammation remains to be resolved. Herein, a sticky and strain‐gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin‐inspired hierarchical structure entailing strain‐gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self‐healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair.
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