肝细胞癌
置信区间
优势比
实体瘤疗效评价标准
血管生成
医学
灌注
危险系数
内科学
超声造影
肿瘤科
泌尿科
胃肠病学
超声波
核医学
放射科
化疗
临床研究阶段
作者
Yi Zhang,Ruiying Zheng,Ming Liu,Xiaoer Zhang,Yueting Sun,Hui Shen,Chao Song,Hongjie Cai,Wenbo Guo,Xian-Jin Xie,Baoxian Liu,Guangliang Huang
标识
DOI:10.1016/j.ultrasmedbio.2023.11.005
摘要
The aim of the work described here was to explore the value of contrast-enhanced ultrasound (CEUS) quantitative parameters in predicting the response of combined immune checkpoint inhibitor (ICI) and anti-angiogenesis therapies for unresectable hepatocellular carcinoma (HCC).Sixty-six HCC patients who underwent combined ICI and anti-angiogenesis therapies were prospectively enrolled. A CEUS examination was performed at baseline, and tumor perfusion parameters were obtained with perfusion quantification software. The differences in CEUS quantitative parameters between the responder and non-responder groups were compared, and the correlations between CEUS parameters and progression-free survival (PFS) was evaluated.The objective response rate (ORR) was 21.2%. The values of rising time (RT) ratio, time to peak ratio, fall time ratio, peak enhancement ratio, wash-in rate ratio, wash-in perfusion index ratio and wash-out rate ratio differed significantly differed between the responder and non-responder groups (all p values < 0.05). Multivariable logistic regression analysis revealed that the RT ratio was the only independent factor associated with the ORR (odds ratio = 0.007, 95% confidence interval: 0.000-0.307, p = 0.010). The median RT ratios of the responder and non-responder groups were 36.9 and 58.9, respectively (p = 0.006). The appropriate cutoff point of the RT ratio was 80.1, determined with the X-tile program. Survival analysis indicated high PFS for the patients with a lower RT ratio (high RT ratio vs. low RT ratio = 4.4 mo vs. not reached, p = 0.001).CEUS quantitative parameters may predict the efficacy of ICI and anti-angiogenesis combined therapies for HCC.
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