范围(计算机科学)
构造(python库)
医学
药物开发
计算机科学
风险分析(工程)
临床试验
药品
计算生物学
医学物理学
药理学
生物
病理
程序设计语言
作者
Virginia Metrangolo,Lars H. Engelholm
出处
期刊:Cancers
[MDPI AG]
日期:2024-01-20
卷期号:16 (2): 447-447
标识
DOI:10.3390/cancers16020447
摘要
Introduced almost two decades ago, ADCs have marked a breakthrough in the targeted therapy era, providing clinical benefits to many cancer patients. While the inherent complexity of this class of drugs has challenged their development and broad application, the experience gained from years of trials and errors and recent advances in construct design and delivery have led to an increased number of ADCs approved or in late clinical development in only five years. Target and payload diversification, along with novel conjugation and linker technologies, are at the forefront of next-generation ADC development, renewing hopes to broaden the scope of these targeted drugs to difficult-to-treat cancers and beyond. This review highlights recent trends in the ADC field, focusing on construct design and mechanism of action and their implications on ADCs' therapeutic profile. The evolution from conventional to innovative ADC formats will be illustrated, along with some of the current hurdles, including toxicity and drug resistance. Future directions to improve the design of next-generation ADCs will also be presented.
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