聚酮
多元醇
绝对构型
立体化学
链霉菌
化学
生物
有机化学
生物合成
细菌
酶
遗传学
聚氨酯
作者
Thanh-Hau Huynh,Hee Kyung Kim,Jayho Lee,Yeon Hee Ban,Yong-Joon Jang,Bo Eun Heo,Thi Hoa Nguyen,Joon Soo An,Y.S. Kwon,Sang‐Jip Nam,Jichan Jang,Ki‐Bong Oh,Myunghun Shin,Dong‐Chan Oh
标识
DOI:10.1021/acs.jnatprod.3c01043
摘要
A new polyol polyketide, named retinestatin (1), was obtained and characterized from the culture of a Streptomyces strain, which was isolated from a subterranean nest of the termite Reticulitermes speratus kyushuensis Morimoto. The planar structure of 1 was elucidated on the basis of the cumulative analysis of ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 at 12 chiral centers was successfully assigned by employing a J-based configuration analysis in combination with ROESY correlations, a quantum mechanics-based computational approach to calculate NMR chemical shifts, and a 3 min flash esterification by Mosher's reagents followed by NMR analysis. Biological evaluation of retinestatin (1) using an in vitro model of Parkinson's disease revealed that 1 protected SH-SY5Y dopaminergic cells from MPP+-induced cytotoxicity, indicating its neuroprotective effects.
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