Predictive pharmacodynamic performance of the Eleveld pharmacokinetic–pharmacodynamic model for propofol: comparison of predicted and measured bispectral index

The Eleveld pharmacokinetic-pharmacodynamic model for propofol predicts bispectral index (BIS) processed electroencephalogram values from estimated effect-site concentrations. We investigated agreement between measured and predicted BIS values during total intravenous anaesthesia (TIVA).