Use of Micro Bioreactor systems to streamline cell line evaluation and upstream process development for monoclonal antibody production

The development of monoclonal antibody (mAb) processes conventionally involves the generation of multiple cell lines in multiwell plates, cell line screening in shake flasks followed by final cell line selection and process optimisation in bioreactors. This process can typically take up to 18 months to generate a robust process suitable for early phase manufacturing and therefore any opportunity to streamline this process impacts directly on drug development timelines.