异构酶
萜类
生物合成
异构化
酶
生物化学
化学
脱质子化
立体化学
催化作用
离子
有机化学
作者
Karine Berthelot,Yannick Estevez,Alain Deffieux,Frédéric Peruch
出处
期刊:Biochimie
[Elsevier]
日期:2012-08-01
卷期号:94 (8): 1621-1634
被引量:142
标识
DOI:10.1016/j.biochi.2012.03.021
摘要
Even if the isopentenyl diphosphate (IPP) isomerases have been discovered in the 50s, it is only in the last decade that the genetical, enzymatical, structural richness and cellular importance of this large family of crucial enzymes has been uncovered. Present in all living kingdoms, they can be classified in two subfamilies: type 1 and type 2 IPP isomerases, which show clearly distinct characteristics. They all perform the regulatory isomerization of isopentenyl diphosphate into dimethylallyl diphosphate, a key rate-limiting step of the terpenoid biosynthesis, via a protonation/deprotonation mechanism. Due to their importance in the isoprenoid metabolism and the increasing interest of industry devoted to terpenoid production, it is foreseen that the biotechnological development of such enzymes should be under intense scrutiny in the near future.
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