医学
眼内淋巴瘤
美罗华
淋巴瘤
甲氨蝶呤
活检
皮肤病科
葡萄膜炎
视力模糊
介绍
眼科
外科
病理
家庭医学
作者
Khawla Abu Samra,Merih Oray,Nazanin Ebrahimiadib,Stacey J. Lee,Stephen D Anesi,C. Stephen Foster
标识
DOI:10.1080/09273948.2016.1193206
摘要
To describe clinical manifestations, diagnostic approaches, therapy, and outcomes of biopsy-proven intraocular lymphoma.Review of tertiary referral center records between 2005 and 2015.A total of 51 eyes of 26 patients were included; mean age of onset was 60.42 years. Common ocular complaints included floaters (42%) and blurred vision (35%); 62% of patients had ocular and central nervous system involvement; 11% had systemic lymphoma; and 27% had only ocular involvement. Vitreous analysis was positive for malignant cells in 77% of patients on initial biopsy, and in 100% of patients on repeat biopsy. In total, 20/26 patients received systemic and topical treatment before IOL diagnosis was made; 25 patients received intravitreal methotrexate and/or rituximab; one patient received intracameral rituximab. All patients achieved remission by their final visit.Intraocular lymphoma often masquerades as intraocular inflammation, resulting in delayed or misdiagnosis with subsequent inappropriate management. Optimal therapy is a challenge for oncologists and ophthalmologists.
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