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选择(遗传算法)
计算机科学
集合(抽象数据类型)
否定选择
序列(生物学)
鉴定(生物学)
计算生物学
达尔文主义
人工智能
生物
互联网
进化生物学
遗传学
万维网
基因
生态学
程序设计语言
基因组
作者
Adi Doron‐Faigenboim,Adi Stern,Itay Mayrose,Eran Bacharach,Tal Pupko
出处
期刊:Bioinformatics
[Oxford University Press]
日期:2005-01-01
卷期号:21 (9): 2101-2103
被引量:137
标识
DOI:10.1093/bioinformatics/bti259
摘要
Summary: We present an algorithmic tool for the identification of biologically significant amino acids in proteins of known three dimensional structure. We estimate the degree of purifying selection and positive Darwinian selection at each site and project these estimates onto the molecular surface of the protein. Thus, patches of functional residues (undergoing either positive or purifying selection), which may be discontinuous in the linear sequence, are revealed. We test for the statistical significance of the site-specific scores in order to obtain reliable and valid estimates. Availability: The Selecton web server is available at: http://selecton.bioinfo.tau.ac.il Contact:selecton@bioinfo.tau.ac.il Supplementary information: More information is available at http://selecton.bioinfo.tau.ac.il/overview.html. A set of examples is available at http://selecton.bioinfo.tau.ac.il/gallery.html
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