抄写(语言学)
肾
转录因子
毒性
镉
DNA
分子生物学
生物
DNA损伤
化学
基因
内科学
内分泌学
生物化学
医学
哲学
有机化学
语言学
作者
Jin‐Yong Lee,Chikage Mori,Maki Tokumoto,Masahiko Satoh
出处
期刊:Journal of Toxicological Sciences
[Japanese Society of Toxicology]
日期:2021-01-01
卷期号:46 (3): 125-129
被引量:2
摘要
Cadmium (Cd) is a toxic heavy metal, long-term exposure to which causes renal damage associated with disruption in gene expression. Transcription factors whose activities were altered in the kidneys of mice exposed to Cd for 3 months were assessed using protein/DNA-binding assays. Female C57BL/6J mice were exposed to 300 ppm Cd in the diet for 3 months. Nuclear extracts of kidney were used for protein/DNA-binding assays. The concentration of Cd was approximately 100 ppm in mouse kidney, a level that did not induce renal toxicity. Among the 345 transcription factors evaluated, five transcription factors showed over a two-fold increase in their activities and 14 transcription factors showed a half-fold change in their activities after Cd exposure. These findings may provide new information about the causative transcription factors associated with Cd renal toxicity.
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