Extremophilic microorganisms are special kinds of beings adapted to extreme environment with isolated evolution relevantly.Their ecology environment is nearly extreme.They have special of structure,physiology traits and molecular evolution mechanisms.Studying the diversity of extremophiles,including thermophiles,psychrophiles,acidophiles,alkaliphiles,barophiles and halophiles,were summarized in this paper.Extremophiles can produce extre-condition enzymes and new biological activated products.Many enzymes have been produced in industrial and applied in practice.