化学
尖孢镰刀菌
异恶唑
枯草芽孢杆菌
细菌
碳-13核磁共振
吡唑
抗菌活性
大肠杆菌
喹唑啉
质子核磁共振
嘧啶
核化学
立体化学
生物化学
植物
生物
基因
遗传学
作者
Ahmed A. Fadda,Ramy Rabie,Samir Bondock,H. A. Etman
摘要
(1,5‐Dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1 H ‐pyrazol‐4‐yl)carbono‐hydrazonoyl dicyanide was used as a key intermediate for the synthesis of novel pyrazole, isoxazole, pyrimidine, and pyridazine derivatives. The newly synthesized compounds were characterized by elemental analyses and spectral data (IR, 1 H‐NMR, 13 C‐NMR, and mass spectra). The compounds were tested for their in vitro antibacterial activity against Gram‐positive bacteria as ( Staphylococcus aureus and Bacillus subtilis ) and Gram‐negative bacteria ( Pseudomonas aeruginosa and Escherichia coli ). The investigated compounds were tested against two strains of fungi Botrytis fabae and Fusarium oxysporum using diffusion agar technique. The biological results showed clearly that most of the synthesized compounds revealed mild to moderate activity against the used microorganisms.
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