表面改性
纳米点
材料科学
二氧化钛
紫外线
光热治疗
骨整合
纳米技术
表面能
生物物理学
化学工程
光电子学
生物
植入
冶金
复合材料
外科
工程类
医学
作者
Chao Liu,Mouyuan Sun,Yu Wang,Tianer Zhu,Guanchen Ye,Dongqi You,Lingqing Dong,Wenquan Zhao,Kui Cheng,Wenjian Weng,Yu Shrike Zhang,Mengfei Yu,Huiming Wang
标识
DOI:10.1021/acsami.0c07761
摘要
Titanium dioxide (TiO2) photofunctionalization has been demonstrated as an effective surface modification method for the osseointegration of implants. However, the insufficient understanding of the mechanism underlying photofunctionalization limits its clinical applications. Here, we report an ultraviolet (UV) radiant energy-dependent functionalization on TiO2 nanodots (TN) surfaces. We found the cell adhesion, proliferation, and osteogenic differentiation gradually increased with the accumulation of UV radiant energy (URE). The optimal functionalizing treatment energy was found to be 2000 mJ/cm2, which could regulate cell-specific behaviors on TN surfaces. The enhanced cell behaviors were regulated by the adsorption and functional site exposure of the extracellular matrix (ECM) proteins, which were the result of the surface physicochemical changes induced by the URE. The correlation between the URE and the reconstruction of surface hydroxyl groups was considered as an alternative mechanism of this energy-dependent functionalization. We also demonstrated the synergistic effects of FAK-RHOA and ERK1/2 signaling pathways on mediating the URE-dependent cell behaviors. Overall, this study provides a novel insight into the mechanisms of photofunctionalization, guiding the design of implants and the clinical practice of photofunctionalization.
科研通智能强力驱动
Strongly Powered by AbleSci AI