化学
酰胺
试剂
羟醛反应
溶剂
惰性
羧酸
小学(天文学)
有机化学
曼尼希反应
组合化学
反应条件
催化作用
天文
物理
作者
Fathima Pilathottathil,Doppalapudi Vineet Kumar,Kaliyamoorthy Alagiri
标识
DOI:10.1080/00397911.2020.1747631
摘要
A straightforward synthesis of acylating reagents such as Weinreb and MAP amides from aromatic, aliphatic carboxylic acids, and amino acids using PPh3/NBS combination is described. A chemo-selective modification of the carboxylic acid group into Weinreb amide in the presence of more reactive aldehydes and ketones is presented. All reactions were performed at ambient temperature under air using undried commercial grade solvent. Furthermore, the present methodology could be performed at a gram scale under inert-free reaction conditions. In addition, 7-azaindoline amide auxiliary (used for catalytic asymmetric aldol- and Mannich-type reactions), which behaves like Weinreb amide is also synthesized under similar reaction conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI