A crystal-to-crystal phase transformation of organic cocrystals in response to multiple external stimuli, such as solvent vapor and heating, accompanied by reversible luminescence switching is described by B. Xu and co-workers in their Communication on page 15098. The results indicate that the luminescence switching originates from the unique molecular rearrangement of a hydrogen/halogen-bond-directed stack into a π–π-interaction-directed stack in response to an external stimulus.