组合化学
表面改性
催化作用
对映选择合成
分子
烷基
纳米技术
化学
灵活性(工程)
材料科学
有机化学
数学
物理化学
统计
作者
Chun Li,Xin Kui,Qinghua Lu,Hangyu Liu,Deyun Qian
出处
期刊:Chem catalysis
[Elsevier]
日期:2024-01-01
卷期号:4 (1): 100798-100798
标识
DOI:10.1016/j.checat.2023.100798
摘要
Enantioenriched, substituted saturated heterocycles extensively occur in natural products, bioactive targets, and organic frameworks. Conventional tools for their synthesis often require engineered precursors that limit the flexibility of the synthetic routes and the diversity of target scaffolds. Therefore, the rapid and diverse synthesis of these heterocyclic molecules is highly desired yet challenging. Undoubtedly, the direct asymmetric functionalization of simple and readily accessible heterocyclic substrates represents one of the most straightforward and efficient solutions. Recently, innovative and modular strategies based on alkyl cross-coupling, directing-group-assisted C–H activation, photocatalytic hydrogen atom transfer (HAT), Heck reaction, and hydro- and difunctionalization have been designed to access chiral saturated heterocyclic motifs, paving the way for their more extensive utilization in future pharmaceuticals. In this perspective, recent progress in the preparation of chiral saturated heterocycles is outlined. How these innovations have enabled new levels of molecular selectivity, complexity, and practicality is also emphasized.
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