先天免疫系统
免疫学
免疫系统
泌尿系统
抗菌剂
抗菌肽
生物
病菌
医学
微生物学
内科学
作者
Hunter W. Kuhn,Teri N. Hreha,David A. Hunstad
标识
DOI:10.1016/j.it.2023.07.001
摘要
Recent advances in preclinical modeling of urinary tract infections (UTIs) have enabled the identification of key facets of the host response that influence pathogen clearance and tissue damage. Here, we review new insights into the functions of neutrophils, macrophages, and antimicrobial peptides in innate control of uropathogens and in mammalian infection-related tissue injury and repair. We also discuss novel functions for renal epithelial cells in innate antimicrobial defense. In addition, epigenetic modifications during bacterial cystitis have been implicated in bladder remodeling, conveying susceptibility to recurrent UTI. In total, contemporary work in this arena has better defined host processes that shape UTI susceptibility and severity and might inform the development of novel preventive and therapeutic approaches for acute and recurrent UTI.
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