Senescence‐Targeted and NAD+‐Dependent SIRT1‐Activated Nanoplatform to Counteract Stem Cell Senescence for Promoting Aged Bone Regeneration

Age-related bone defects are a leading cause of disability and mortality in elderly individuals, and targeted therapy to delay the senescence of bone marrow-derived mesenchymal stem cells (MSCs) has emerged as a promising strategy to rejuvenate bone regeneration in aged scenarios. More specifically, activating the nicotinamide adenine dinucleotide (NAD