纳米医学
纳米载体
材料科学
纳米技术
纳米颗粒
药物输送
活性氧
癌症治疗
癌细胞
癌症
化学
生物化学
医学
内科学
作者
Ruizhi Hu,Xiaoying Chen,Zhifang Li,Guangbo Zhao,Li Ding,Liang Chen,Chen Dai,Yu Chen,Chao Zhang
标识
DOI:10.1002/adma.202306469
摘要
Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion-involved cancer-therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)-responsive organosilica network is employed to lock the liquid drops at the nanoscale via a general bottom-up strategy to achieve the systemic delivery of "ion drugs". In this work, a sulfate radical generation donor (Na2 S2 O8 ), as a paradigm "ion drug", is entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH-responsive tannic acid-Fe2+ framework, these liquid nanoparticles achieve tumor-microenvironmental pH/GSH-dual responsive ion release (Fe2+ /Na+ /S2 O82- ) after reaching the tumor sites, where the Fe2+ further triggers S2 O82- to generate toxic •SO4- and •OH, effectively executing cancer cell ferroptosis (Fe2+ , reactive oxygen species-ROS) and pyroptosis (Na+ , ROS). Such a tumor-responsive/specific liquid nanoplatform is highly instructive for further ion-mediated nanomedicine and disease treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI